Can Fisetin Slow Aging by Protecting Vital NAD+ Levels?

NAD+ is a vital molecule found in nearly every cell, helping turn food into energy and supporting tasks like DNA repair. As people age, levels of this molecule decline due to both reduced production and increased consumption—partly driven by senescent cells. Now, research suggests that fisetin, a natural compound found in fruits and vegetables, may help preserve NAD+ by targeting these ageing-related processes.

Senescent cells build up over time and release inflammatory signals. These cells also boost the activity of enzymes like CD38, which break down NAD+ faster. The result is a double challenge: the body makes less NAD+ while using up more of it.

Fisetin, a flavonoid found in strawberries and other produce, has been studied for its ability to clear out senescent cells. In longevity circles, it is used either as a daily supplement or in short, high-dose bursts—sometimes called 'pulsing'. By reducing inflammation and removing damaged cells, fisetin may create a more stable environment for NAD+.

Scientists have explored fisetin alongside quercetin in senolytic research, focusing on how these compounds might slow age-related decline. While not a direct NAD+ booster, fisetin could indirectly support NAD+ levels by lowering cellular stress. This makes it a common addition to strategies aimed at brain health and longevity.

Testing NAD+ levels can help track whether such approaches, including fisetin use, are effective.

Fisetin's potential to clear senescent cells and reduce inflammation offers a way to support NAD+ balance as people age. By improving the cellular environment, it may help the body retain this essential molecule more efficiently. Further research and testing will clarify its long-term role in longevity strategies.