Kirigami-Inspired Microelectrodes Revolutionize Long-Term Brain Activity Tracking

Scientists have created a flexible microelectrode array inspired by kirigami to record brain activity in primates over long periods. The new device overcomes problems with older rigid implants, which often damage tissue and lose signal quality. Tests in macaque monkeys show it can track hundreds of neurons at once with high precision.

The array uses a reconfigurable spiral thread design that moves with the brain's natural shifts. Unlike stiff traditional implants, these stretchable threads float on the surface, reducing inflammation and scarring. Their kirigami structure allows them to bend and stretch without breaking or losing electrical function.

The device is implanted using a water-soluble carrier coated in hydrogel. Once in place, the carrier dissolves, leaving the ultra-thin threads spread across large areas of the motor cortex. In trials, the arrays recorded activity from over 700 neurons simultaneously, capturing detailed spiking patterns.

Researchers used the data to decode upper-limb movements with high accuracy. The broad coverage of the spiral threads also makes them useful for studying complex neural circuits. This could pave the way for better brain-machine interfaces in the future.

The kirigami-inspired array offers a more reliable way to monitor brain activity long-term. Its ability to adapt to the brain's movement reduces damage and improves signal quality. These advances may help scientists develop more effective tools for neuroscience and medical applications.